The Q5’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The CX-50 doesn’t offer pre-crash pretensioners.
Both the Q5 and CX-50 have child safety locks to prevent children from opening the rear doors. The Q5 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The CX-50’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
When descending a steep, off-road slope, the Q5’s standard Hill Descent Control allows you to creep down safely. The CX-50 doesn’t offer Hill Descent Control.
The Audi Q5 comes with a standard Top View Camera System with a rear camera washer to provide all-weather visibility, regardless of road dirt or grime, while the Mazda CX-50 doesn’t offer a camera washer, requiring manual cleaning.
To help make backing out of a parking space safer, the Q5 has standard Rear Cross-Traffic Assist with Automatic Brake Activation, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Only the CX-50 Turbo Premium Plus offers Rear Cross Traffic Braking.
Both the Q5 and the CX-50 have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available around view monitors.

